侯建維
個人資訊 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴
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姓名 |
侯建維 Rolis, Chien-Wei Hou |
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職稱 |
教授 |
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電話 傳真電話 |
03-538-1183 # 8161 03-6102312 |
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辦公室位置 |
H405 |
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信箱 |
rolis.hou@mail.ypu.edu.tw |
學 歷 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴
國立中興大學 生物科技學研究所 博士
國立中興大學 分子生物學研究所 碩士
私立中國醫藥大學 醫事技術學系 學士
經 歷 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴
台中榮民總醫院醫學研究部博士後研究員
國立勤益科大, 靜宜大學, 弘光科大, 兼任助理教授
仁德醫專 醫檢科 專任 助理教授
元培科大 生技系專任 副教授
喬志亞生技,喬本生醫,滬蘴生技,湧傑生技...等公司, 生技顧問
國外專業期刊編審：
Associate Editor of Journal of Scientific Review
Molecules
Journal of Traditional and Complementary Medicine
Annual Research & Review in Biology
International Journal of Molecular Sciences
International Journal of Food Microbiology
Iranian Journal of Basic Medical Sciences
Journal of Functional Foods
European Journal of Medicinal Plants
Experimental and Therapeutic Medicine
Chinese Medical Journal
Antioxidants
研究領域 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴
中草藥生物科技與生物醫學、中草藥生物科技研究與應用
學術著作 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴
專利發明
1. 一種利用植物油體為菌種載體之生物晶球及其方法；2001/12/25，專利案號 I 312367，專利期間：2009/07-2022/01。
2. 芝麻素及芝麻醇素用於預防中風及保護神經退化之用途；專利案號91132543，2002/09/24，專利期間：2007/3-2025/3。
3. 具有調節代謝體脂之薏仁油；專利案號93135135；證書號數：發明第I 297259，2004/11，專利期間：2008/06-2024/11
4. 肝癌細胞抑制劑；專利申請字號93137016, 2004/12，（申請臺灣專利）。
5. 增效型鳳梨萃取物(Bromelain)製劑及其醫藥組成物，專利申請字號94107926, 2005/03，（申請臺灣專利）。
6. 接菌發酵的普洱茶製法，專利申請字號97105190, 2008/02，（申請歐盟、臺灣專利）。
7. 冬蟲夏草（Cordyceps militaris）菌絲體提升雄性生殖力之用途；發明第 I 298258，2006/03/04，專利期間：2008/07-2026/03
8. 芝麻素萃取之製程，專利申請字號94144300, 2005/12/14，（申請臺灣專利）。
9.增效型鳳梨萃取物，申請案號11/119,861，2005/5/2 (日本)
10.乳癌細胞抑制劑，專利申請字號95123680, 2006/6/29，（申請臺灣專利）。
11. 冬蟲夏草菌絲體及子實體之培養方法與液態培養基，專利申請字號97119969, 2008/05/29，（申請臺灣專利）。
12. 芝麻素衍生物抗神經傷害之用途 發明第 I 466667號。 專利期間：2015/01-2033/03
13. 龍眼籽萃取物的製備方法及其應用發明第 I 466678號。專利期間：2015/01-2029/09
14.用於促進排尿之草本組合物，發明第 I488634號。
15.用於排尿的草本組合，專利字號: CN-102813729-B (大陸）。
16.一种神经保护性组合物及其应用，專利字號: CN 103520143 B (大陸專利）。
17.一种龙眼核萃取物的制备方法与应用 ，專利字號: CN 104147205 B (大陸）。
18.一种龙眼核萃取物的制备方法与应用 ，專利字號: CN 104257837 B (大陸）。
19.リュウガン種子抽出物の製造方法及びその応用 特許第5946508號 (日本) ⸰
20.龍眼籽萃取物的製備方法及其應用，發明第：I564016號。
發表論文:
1. Po-Yuan Wu, Tzu-Yu Lin, Chien-Wei Hou,…Hsiu-Mei Chiang*. 1,2-Bis [(3-Methoxyphenyl) Methyl]Ethane-1,2-Dicarboxylic Acid Reduces UVB-Induced Photodamage In Vitro and In Vivo. Antioxidants. 2019. 8: 452. (Impact Factor: 4.52).
2. Tzu-Yu Lin, Po-Yuan Wu, Chien-Wei Hou, …Hsiu-Mei Chiang*. Protective effects of sesamin against UVB-induced skin inflammation and photodamage in vitro and in vivo. 2019. Biomolecules. 9 (9).479. (Impact Factor: 4.69).
3. Ya-Jhen You, Po-Yuan Wu, Yi-Jung Liu, Chien-Wei Hou, … Hsiu-Mei Chiang*. Sesamol Inhibited Ultraviolet Radiation-Induced Hyperpigmentation and Damage in C57BL/6 Mouse Skin. Antioxidants. 2019, 8: 207.
4. Chien-Wei Hou, I-Chen Chen, Fang-Rui Shu, Chin-Hsing Feng, Chang‐Tsen Hung* Protective effect of supplementation with Lycium ruthenicum Murr. extract from exhaustive exercise-induced cardiac injury in rats. Chinese Medial Journal. 2019, 132: 1005-1006.
5. Po-Yuan Wu, Ya-Jhen You, Yi-Jung Liu, Chien-Wei Hou, … Hsiu-Mei Chiang*. Sesamol inhibited melanogenesis by regulating melanin-related signal transduction in B16F10 cells. International Journal of Molecular Sciences. 2018, 19, 1108.
6. Chang-Tsen Hung, Yuh-Shuen Chen,…C.W. Hou*, Amelioration of carbon tetrachloride-induced hepatic injury by emulsified Antrodia extract. IJBMS. 2018; 21:230-235.
7. Chang‐Tsen Hung, Li-Dian Chen, C.W. Hou*. Neuroprotection of a sesamin derivative, 1, 2-bis [(3-methoxy- phenyl) methyl] ethane-1, 2-dicaroxylic acid (MMEDA) against ischemic and hypoxic neuronal injury. Iranian Journal of Basic Medical Sciences, IJBMS. 2017, 12: 1324-1330.
8. Ching-Hsiao Lee, Yuh-Shuen Chen, C.W. Hou, Kee-Ching Jeng, Anti-inflammatory effect of Longan seed extract in carrageenan stimulated Sprague-Dawley rats. IJBMS. 2016,19: 870-874.
9. Wang, C.K.*, Hou, C.W. and Liu, Z.H. 2016. Decontamination of Alachlor by Continuously Dosed Sono-fenton Process: Effects of System Parameters and Kinetics Study. Modern Environmental Science and Engineering. Volume 2, No. 1, pp. 1-10.
10. Chi-KangWang, C.W. Hou, Jhong-Jheng Jian, 2014. Degradation of Tetracyclines Antibiotic Wastewater by Processes of Assisted Sonolysis Journal of Health Management. 12(2): 43-53.
11. An-Chi Shao, Chien-Wei Hou, Kee-Ching Jeng*. 2015. Effect of sesamin on apoptosis and cell cycle arrest in human breast cancer MCF-7 cells. APJCP. 16 (9): 3779-3783.
12. Cheng-Yao Yang, Lu-Te Chuang*, Wen-Cheng Huang, Chien-Wei Hou, et al.,. 2014. Preventive effects of borage oil and Ling-Zhi-8 protein on carbon tetrachloride-induced acute hepatic toxicity in rats. Current Topics in Nutraceutical research. 12: 91-100.
13. Chien-Wei Hou, Shun Yu Chang, Kee Ching Jeng*.2015. Protective effect of a sesamin derivative, 3-bis (3-methoxybenzyl) butane-1, 4-diol on Aβ-stressed PC12 cells. Archives of Pharmacal Research (ARPR).0426-1.
14. Wen-Hung Lin, An-Ci Siao, Kee-Ching Jeng, Chien-Wei Hou*, 2015. Gardenia jasminoides Extracts and Gallic Acid Inhibit Lipopolysaccharide-Induced inflammation by Suppression of JNK2/1 Signaling Pathways in BV-2 cells. 2015; 18 (6): 555-62. IJBMS.
15. Chien-Wei Hou, Yi-Ling Chen, Kee Ching Jeng*. 2014. Protective effect of a sesamin derivative, 3-bis (3-methoxybenzyl) butane-1, 4-diol on ischemic and hypoxic neuronal injury. J. Biomedical Sci. 21:15.
16. Wen-Hung Lin, Chien-Wei Hou* et al., 2014. Peanut Root Extracts and Resveratrol Inhibit Lipopolysaccharide-Induced inflammation by Suppression of MAPKs Signaling Pathways in BV-2 cells. Indian J. Agric. Res, 48 (1): 16-22.
17. Wen-Chieh Lin, Yu-Fen Peng, Chien-Wei Hou*, 2015. Ferulic acid protects PC12 neurons against hypoxia by inhibiting the p-MAPKs and COX-2 pathways. IJBMS. 2015; 18 (5): 478-84.
18. Hsiu-Mei Chiang, Hsiang Chang, Pei-Wun Yao, Yuh-Shuen Chen, Kee-Ching Jeng, Jen-Shu Wang, Chien-Wei Hou*, 2014. Sesamin reduces acute hepatic injury induced by lead coupled with lipopolysaccharide. Journal of the Chinese Medical Association. 77: 227-233.
19. Chi-Kang Wang,* Chien-Wei Hou, Yu-Xiu Wei. 2013. Degradation and detoxicity of ethylenediamine wastewater by a continuous dosing mode sono-Fenton process. Sustain. Environ. Res., 23(6), 413-420.
20. Jau-Tien Lin, Yi-Chen Chen, Ying-Chung Lee, C.W. Hou, Fong-Lin Chen, Deng-Jye Yang, 2012. Antioxidant, anti-proliferative and cyclooxygenase-2 inhibitory activities of ethanolic extracts from lemon balm leaves. LWT - Food Science and Technology. 49 (1), 1-7.
21. Chien-Wei Hou, Ying-Chung Lee, Hsiao-Fang Hung, Kee-Ching Jeng. 2012. Longan seed extract reduces hyperuricemia via modulating urate transporters and suppressing xanthine oxidase acitivity. The American Journal of Chinese medicine. 40 (5): 979-991.
22. Hsiao-Ling Huang, Kee-Ching G. Jeng, Pei-Wun Yao, Lu-Te Chuang, Chien-Wei. Hou*. 2012. Fresh Green Tea and Gallic Acid Ameliorate Oxidative Stress in Kainic Acid-Induced Status Epilepticus. Journal of Agricultural and Food Chemistry. 60: 2328-2336.
23. Chien-Wei Hou, Yu-Tzy Lin, Yi-Ling Chen, Kee-Ching Jeng, et al., 2012. Neuroprotective effects of carnosic acid on neuronal cells under ischemic and hypoxic stress. Nutri Neurosci. 15: 257-263.
24. Chien-Wei. Hou*. 2011. Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticus. Journal of biomedical Sci. 18: 75.
25. Lu Te Chuang, Robert H. Glew, Yuan Chen Wang, Pei Wun Yao, Chien Wei Hou*. 2011. Comparison of the fatty acid, amino acid, mineral and antioxidant content of sweet potato leaves grown on Matsu Island and mainland Taiwan. FOOD. 5: 43-47.
26. Peiyuan F Hsieh, Pei Wun Yao, Kee Ching Jeng, and Chien-Wei Hou*. 2011. Sesamin ameliorates oxidative stress and mortality in kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation. Journal of Neuroinflammation. 8 (57): 1-10 (Impact Factor: 5.8).
27. Hsiao-Fang Hung, C.W. Hou, Yi-Ling Chen, Kee-Ching Jeng. (2011). Elephantopus scaber inhibits lipopolysaccharide-induced liver injury by suppression of signaling pathways in rats. The American Journal of Chinese medicine. 39: 705–717.
28. Jian-Gong Liu, Chien-Wei Hou, Shin-Yi Lee, Yaju Chuang, Chih-Cheng Lin. (2011). Antioxidant Effects and UVB Protective Activity of Spirulina (Arthrospira platensis) products Fermented with Lactic Acid Bacteria. Process Biochemistry. 46: 1405–1410. (I F:2.65).
29. Juen-Haur Hwang, I-Te Lee, Kee-Ching Jeng, Ming-FuWang, Rolis Chien-Wei Hou, Su-MeiWu, Yin-Ching Chan. (2011). Spirulina prevents memory dysfunction, reduces oxidative stress damage and augments antioxidant activity in senescence-accelerated mice. Journal of Nutritional Science and Vitaminology. 57: 186-191.
30. Hou, C. W., Kee Ching Jeng, Yuh Shuen Chen. (2010). Enhancement of Fermentation Process in Pu-Erh Tea by Tea-Leaf Extract. Journal of Food Science. 75: H44-48.
31. Jing-Rong Huang, Chia-Chuan Wu, C.W. Hou, Kee-Ching G. Jeng, (2008). Bromelain inhibits lipopolysaccharide-induced cytokine production in human THP-1 monocytes via the removal of CD14 and suppression of MAPK pathways. Immunological Investigations. 37: 263–277.
32. Chang,Y., K.C. Jeng, K. F. Huang, Y. C. Lee, C. W. Hou, K. H. Chen, F. Y. Cheng, J. W. Liao, Y. S. Chen. (2008). Effect of Cordyceps Militaris supplementation on sperm production, sperm motility and hormones in Sprague-Dawley rats. The American Journal of Chinese medicine. 36: 849-859.
33. Cheng, Fu-Yen, C. W. Hou, C. T. Lu, C.M. Lin, Aiko Hirashima. (2007). aesthetic study on physical appearance of the length of cervical vertebrae and lower extremities. The Journal of international Esthetic Science. V-4-2-5. (TSSCI).
34. K. C. G. Jeng, C. S. Chen, Y. P. Fang, R. C. W. Hou, and Yuh-Shuen Chen, (2007). Effect of Microbial fermentation on content of Statin, GABA, and polyphenols in Pu-Erh tea. Journal of Agricultural and Food Chemistry. 55: 8787-8792.
35. W. H. Lin, Y. S. Chen, M. T. Tsai, R. C. W. Hou, H. F. Hung, C. H. Li, H. K. Wang, M. N. Lai and K. C. G. Jeng. (2007). Effect of Cordyceps militaris supplement on sperm production in adult boars. The American Journal of Chinese medicine. 35: 637-647.
36. Cheng, F. Y, C. Tsai, C. W. Hou, et al, (2006). Aesthetic study on physical appearance of Calcaneus & patella. The Journal of international Esthetic Science. V-3-2-7. (TSSCI).
37. Cheng FC, Jinn TR, R. C. W. Hou, Tzen JTC (2006). Neuroprotective effects of sesamin and sesamolin on gerbil brain in cerebral ischemia. Int J Biomed Sci. 2: 284-288.
38. Tsai, C. Cheng F. Y, C. W. Hou, et al, (2006). Neutron activation analysis of natural superconductor ore material applying in cosmetology and biotechnology taking superconductor white diamond as research analysis case. The J. Inter. Esthetic Sci. V-3-2-1. (TSSCI).
39. Tsai, C. Cheng F. Y, C. W. Hou, et al, (2006). Ellagic acid the research of in microemulsion cosmetic application. The Journal of international Esthetic Science. V-3-2-9. (TSSCI).
40. Cheng F. Y, C. Tsai, C. W. Hou, et al, (2006). Aesthetic study on physical appearance of foot-bone & hand- bone. The Journal of international Esthetic Science. V-3-2-2. (TSSCI).
41. P. C. Liao, R. C. W. Hou, J. S. Wang, and K.C. G. Jeng. (2006). Enhancement of the release of inflammatory mediators by substance P in rat basophilic leukemia RBL-2H3 cells. Journal of biomedical Sci. 13: 613-619.
42. Rolis Chien-Wei Hou, Yuh-Shuen Chen, Chia-Hsin Chen, and Kee-Ching G. Jeng (2006). Protective effect of 1, 2, 4-benzenetriol on LPS-induced NO production by BV2 microglial cells. Journal of biomedical Sci. 13: 89-99.
43. Hou, R C. W. Yuh-Shuen Chen, Jing-Rong Huang, and Kee-Ching g. Jeng. (2006). Cross-Linked Bromelain Inhibits Lipopolysaccharide-Induced Cytokine Production Involving Cellular Signaling Suppression in Rats. Journal of Agricultural and Food Chemistry. 54: 2193-2198.
44. K. C. G. Jeng, and Hou, R C. W. (2005). Sesamin and sesamolin: nature’s therapeutic lignans. Current Enzyme Inhibition. 1: 11-20. (Review article).
45. Jeng, K. C., Hou, R. C., Wang, J. C., Ping, L. I. (2005). Sesamin inhibits lipopolysaccharide-induced cytokine production by the suppression of p38 mitogen-activated protein kinase and nuclear factor-kB. Immunol Lett. 97: 101-106.
46. Hsueh-Meei, Huang Hsio-Chung, OU, Huan-Lian Chen, Rolis Chien-Wei Hou, Kee Ching G. Jeng, (2005). Protective Effect of a-Keto-b-Methyl-Valeric Acid on BV-2 Microglia under Hypoxia or Oxidative Stress. Annals of the New York Academy of Sciences. 1042: 272-278.
47. Hou, R C. W., C. C. Wu, J. R. Huang. Y. S. Chen, and K. C. G. Jeng, (2005). Oxidative Toxicity in BV-2 Microglia Cells: Sesamolin Neuroprotection of H2O2 Injury Involving Activation of p38 Mitogen-Activated Protein Kinase. Annals of the New York Academy of Sciences. 1042: 279-285.
48. Hou, R. C. W., C. C. Wu, and K. C. G. Jeng, (2004). Protective effects of sesamin and sesamolin on BV-2 microglia under hypoxia. Neurosci Letters. 367: 10-13. (I F: 2.146)
49. Chang, J. C., C. H. Yang, P. Y. Chou, R. C. W. Hou, K. C. G. Jeng, C. C. Cheng, and L. Sheh. (2004). DNA Sequence-specific Recognition of Polyamide-peptide Conjugates Incorporating the HPRK Motif. Bioorganic Medicine Chem. 12: 53-61.
50. Hou, R. C. W., M. Y. Lin, M. M. C. Wang, and J. T.C. Tzen, (2003). Increase of viability of entrapped cells of lactobacillus delbrueckii ssp. bulgaricus in artificial sesame oil emulsions. J. Dairy Sci. 86: 424-428
51. Hou, R. C. W., H. L. Chen, J. T.C. Tzen, and K. C. G. Jeng, (2003). Effect of sesame antioxidants on LPS-induced NO production by BV2 microglial cells. NeuroReport. 14:1815-18159.
52. Hou, R. C. W., H. M. Huang, J. T.C. Tzen, and K. C. G. Jeng, (2003). Protective effects of sesamin and sesamolin on hypoxic neuronal and PC12 cells. J. Neurosciece Research. 74:123-133.
53. Lee, T. T. T., M. M. C. Wang, R. C. W. Hou, L. J. Chen, R. C. Su, C. S. Wang, and J. T. C. Tzen, (2003). Enhanced methionine and cysteine levels in transgenic rice seeds by the accumulation of sesame 2S albumin. Biosci Biotechnol Biochem. 67: 1699-1705.
研討會論文:
1. Hou, R C. W, C. C. Wu, J. R. Huang, Y. S. Chen, K. C. G. Jeng. 2004,10,10. Oxidative Toxicity in BV-2 Microglia Cells: Sesamolin Neuroprotection of H2O2 Injury Involving Activation of p38 Mitogen-Activated Protein Kinase. Annals of the New York Academy of Sciences. the 2nd Scientific Meeting of Asian Society for Mitochondrial Research and Medicine (ASMRM). International meeting hall, Taipei, Taiwan. 279-285.
2. 侯建維、張淑婷、林志城、莊路德. 2009,3,7. Sesamin Protects liver from Lead coupled with Lipopolysaccharide Induced Acute Hepatitis Injury芝麻素對鉛與脂多醣體所引發的急性肝損傷影響. 2009 國際學生學術論文發表會.元培科技大學, 新竹市, 臺灣.
3. 侯建維、林志城、鄭啟清、姚佩雯、張淑婷、莊路德. 2010,3,16. 沒食酯酸藉由抑制第二型環化氧化酶活性以達到保護由卡因酸造成之PC12神經細胞之癲癇傷害. 2010國際生技保健學術研討會暨多國學生論文發表會. Yuanpei University, Hsinchu, Taiwan.
4. Chien-Wei. Hou, Pei-Wun Yao, Szu-Pei Wu, Lu-Te Chuang, Yu -Tzu Lin, 2010,12,3. Sesamin protects PC12 cells from kainic acid injury by inhibition of ERK expression. 台灣食品科學技術學會(第十四次年會). 1.E-28.
5. Yi-Ling Chen, Chien-Wei Hou, Hsiao-Fang Huang, Chih-Cheng Lin, Hua-Wen Fu, Jen-Shu Wang, Kee-Ching Jeng. 2011,3,15. Elephantopus scaber Inhibits Lipopolysaccharide-Induced Liver Injury by suppression of Signaling pathways in Rats. 2011 International Students Academic Presentation. 1. 13.
6. Chien-Wei Hou, Pei-Wun Yao, Szu-Pei Wu, Yu-Fen Peng, Yun-Chang Yeh. 2011, 3,15. Sesamin ameliorates oxidative stress and mortality In kainic acid-induced status epilepticus by inhibition of MAPK and COX-2 activation. 2011. International Students Academic Presentation. 1. 17.
7. Chien-Wei Hou, Yu-Tzy Lin. 2011,3,15. Protective Effects of Carnosic acid on Hypoxic PC12 Cells. 2011 International Students Academic Presentation. 1. 19.
8. 侯建維、葉雲彰.普洱茶對於抗氧化作用探討 (Studies on the antioxidative effect of Pu-Erh tea leaf extract). 2011健康與管理學術研討會
9. 侯建維、陳宜伶.在缺氧狀態下芝麻素衍生物3-bis(3-methoxybenzyl)butane-1,4-diol.保護BV-2細胞之影響. 2012健康與管理學術研討會
10. 侯建維、林惠雯.小鼠黑色素瘤細胞添加芝麻醇素對黑色素生成的累積之研究.2012健康與管理學術研討會
11. 侯建維、蕭安淇.梔子花抗發炎功效. 2012健康與管理學術研討會
12. Ma, Y.S., Hou, C.W. and Liu, Z.H. (2013) Decontamination of alachlor herbicide wastewater by a continuous dosing mode ultrasound/Fe2+/H2O2 process. Oral presentation in the 5th IWA-Aspire Conference & Exhibition (Daejeon, Korea) (2013.9.8-2013.9.12).
13. Hou,Chien-Wei, Zhang,Wei-Zh, Hsueh, Chih-Chi, The Anti-inflammatory study of small molecules new dosage forms from Antrodia cinnamomea, 2014 International Studentd Academic Conference國際醫護技職教育學術研討會暨國際學生學術論文研討會, 2014/11/7.
14. Yi-Chen Wang1, Chiou-Fang Liu2, Wen-Ru Yang1, Chih-Cheng Lin1*, Rolis Chien-Wei Hou1*. Study on the effect of Chrysanthemum leaf tea extract against UV light damage of the optic nerval APRE-19 cells. 2016 Asia-Pacific Tea Expo (APTE) Sept. 29 – Oct. 2, 2016, at Taipei International Convention Center (TICC).
15. 侯建維、王苡蓁 芝麻素衍生物3-bis(3-methoxybenzyl) butane-1,4-diol保護ARPE-19細胞氧化逆境之研究.2017健康與管理學術研討會.2017/11/3.
16. 侯建維、許芳瑞 黑枸杞萃取物抗肝臟發炎之研究與分析.2017健康與管理學術研討會.2017/11/3.
17. 莊添旺、侯建維. 天麻、天麻素改善由卡英酸誘發癲癇型式的神經發炎反應.2018生命教育暨健康管理國際學術研討會.2018/10/17.
