莊路德
個人資訊 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴
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姓名 |
莊路德 |
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職稱 |
教授 |
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電話 傳真電話 |
03-5381183 # 2310 (+886) 3-610-2312 |
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辦公室位置 |
H502 |
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信箱 |
ltchuang@mail.ypu.edu.tw |
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學 歷 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴
美國俄亥俄州州立大學營養博士
經 歷 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴
元培醫事科技大學健康學院 院長 (2021-迄今)
元培醫事科技大學生物科技暨製藥技術系 系主任 (2013-迄今)
元培醫事科技大學生物科技暨製藥技術系 教授 (2016-迄今)
元培醫事科技大學生物科技暨製藥技術系副教授 (2012-2016)
元培科技大學生物技術系助理教授 (2006-2012)
益生生技開發股份有限公司資深研究員暨研發產程主管 (2005-2006)
Consultant, Strategic Research & Development, Abbott Laboratories-Ross Products Division, Columbus, OH, US (1999-2004)
研究領域 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴
l 高價值多元不飽和脂肪酸抗發炎、抗癌…等保健功效的研究 (包括功效評估、活性成分的鑑定及作用機制的探討)
l 特殊多元不飽和脂肪酸代謝與生物活性的研究
l 靈芝免疫蛋白特性的研究
l 利用遺傳工程技術改造酵母菌來製造高價值的多元不飽和脂肪酸 (polyunsaturated fatty acid; PUFA)
l 特殊油脂 (modified lipids) 在保健食品上的研發
l 各式脂肪酸組成的分析與定量
實驗室技術
l Lipid extraction, purification, and analysis
l Chemical fatty acid synthesis
l Chromatographic techniques like thin layer chromatography (TLC), gas liquid chromatography (GLC) and high-pressure liquid chromatography (HPLC)
l All standard protein manipulation protocols, (e.g., denaturing and non-denaturing PAGE, western blotting, biochemical assay etc.)
l Detection of various kinds of biochemical mediators, including eicosanoids, cytokines and transcriptional factors
l Molecular biology techniques: including DNA and RNA extraction and purification, agarose gel electrophoreses, and Southern and Northern hybridization protocols.
l Microbiology and cell culture techniques
期刊論文 ╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴╴
五年內執行計畫
l 探討熟米麴抑制發炎反應的功效與機制：以「葡聚醣硫酸鈉誘導腸炎」為模型，輔以「酸性鞘磷脂酶-膜脂質組成」檢測模式 (110-2320-B-264-001-)，行政院科技部 (2021/08–2022/07；主持人)
l 研究葫蘆烷TCD抑制酸性鞘磷脂酶介入發炎性腸道疾病的功效與機制 (108-2320-C-264-001-MY2)，行政院科技部 (2019/08–2021/07；主持人)
l 研究山苦瓜葉三萜類化合物的抗發炎活性 (107-2813-C-264-001-B)，行政院科技部補助大專學生研究計畫 (2018/07–2019/02；指導教授)
l 利用大鼠類風濕性關節炎模型研究靈芝免疫蛋白LZ-8抑制關節炎的功效與機制 (106-2320-B-264-001-)，行政院科技部 (2017/08–2018/07；主持人)
l 利用人類單核球與肝細胞共同培養模型研究松子油酸與其代謝產物調節發炎介質生成與脂質堆積的功效與機制 (105-2320-B-264-001-)，行政院科技部 (2016/08–2017/07；主持人)
l 蓖麻油酸生物活性的探討 (105-2815-C-264-003-B)，行政院科技部補助大專學生研究計畫 (2016/07–2017/02；指導教授)
l 松子油酸調節人類角質細胞增殖與轉移的影響 (105-2815-C-264-004-B)，行政院科技部補助大專學生研究計畫 (2016/07–2017/02；指導教授)
l 「105年度安全機能性產品產業價值鏈之優化整合與加值推動委辦研究計畫 – 紫芽茶機能性成分萃取與應用」 (105AS-16.3.1-TS-T2)，行政院農委會 (2016/01–2016/12；協同研究人員)
l 利用小鼠耳朵腫脹模型研究松子油酸與其加長代謝產物調節發炎介質的功效與機制 (104-2320-B-264-002-)，行政院科技部 (2015/08–2016/07；主持人)
五年內發表著作
l Chuang, L.-T., Huang, W.-C., Hou, Y.-C., Chyuan, J.-H., Chang, H., Chang, C.-I., Tsai, T.-H., and Tsai, P.-J. (2021) Suppressive effect of two cucurbitane-type triterpenoids from Momordica charantia on Cutibacterium acnes-induced inflammatory responses in human THP-1 monocytic cell and mouse model. Molecules 26: 579. (SCI Paper)
l Chuang, L.-T., Lin, Y.-H., Huang, W.-C., Lin, L.-C., Hsu, C., Chyuan, J.-H., Tsai, T.-H., and Tsai, P.-J. (2020) In vitro and in vivo screening of wild bitter melon leaf for anti-inflammatory activity against Cutibacterium acnes. Molecules 25: 4277. (SCI Paper)
l Chen, S.-J., Huang, W.-C., Shen, H.-J., Chen, R.-Y., Chang, H., Ho, Y.S., Tsai, P.-J., and Chuang, L.-T.* (2020) Investigation of modulatory effect of pinolenic acid (PNA) on inflammatory responses in human THP-1 macrophage-like cell and mouse models. Inflammation 43: 518-531. (SCI Paper)
l Chen, T.-Y., Hsieh, Y.-T., Huang, J.-M., Liu, C.-J., Chuang, L.-T., Huang, P.-C., Kuo, T.-Y., Chia, H.-Y., Chou, C.-Y., Chang, C.-W., Chen, Y.-F., Chen, H.-M., Lo, J.-F., and Li, W.-C. (2019) Determination of pyruvate metabolic fates modulates head and neck tumourigenesis. Neoplasia 21: 641-652. (SCI Paper)
l Chuang, L.-T., Tsai, T.-H., Lien, T.-J., Huang, W.-C., Liu, J.-J., Chang, H., Chang, M.-L., and Tsai, P.-J. (2018) Ethanolic extract of Origanum vulgare suppresses Propionibacterium acnes-induced inflammatory responses in human monocyte and mouse ear edema models. Molecules 23: 1987. (SCI Paper)
l Tsai, P.-J., Huang, W.-C., Lin, S.-W., Chen, S.-N., Shen, H.-J., Chang, H., and Chuang, L.-T.* (2018) Juniperonic acid incorporation into the phospholipids of murine macrophage cells modulates pro-inflammatory mediator production. Inflammation 41: 1200-1214. (SCI Paper)
l Tsai, P.-J., Chang, M.-L, Hsin, C.-M., Chuang, C.-C., Chuang, L.-T., and Wu, W.-H. (2017) Anti-lipotoxicity activity of Osmanthus fragrans and Chrysanthemum morifolium flower extracts in hepatocytes and renal glomerular mesangial cells. Mediators Inflamm. 2017: ID 4856095. (SCI Paper)
l Chen, S.-J., Lin, H.-H., Huang, W.-C., Tsai, P.-J., Chen, W.-P., Chen, D.-C., and Chuang, L.-T.* (2017) Ling-Zhi-8 protein (LZ-8) suppresses the production of pro-inflammatory mediators in murine microglial BV-2 cells. Food Agri. Immunol. 28: 1393-1407. (SCI Paper)
l Yang, T.-T., Ho, S.-C., Chuang, L.-T., Chuang, H.-C., Li, Y.-T., and Wu, J.-J. (2017) Characterization of particulate-phase polycyclic aromatic hydrocarbons emitted from incense burning and their bioreactivity in RAW264.7 macrophage. Environ. Pollut. 220: 1190-1198. (SCI Paper)
l Tsai, H.-P., Chuang, L.-T.+, and Chen, C.-N. (2016) Production of long chain omega-3 fatty acids and carotenoids in tropical areas by a new heat-tolerant microalga Tetraselmis sp. DS3. Food Chem. 192: 682-690. (SCI Paper)
研討會論文
l J.-T. Liou, and Chuang, L.-T. (2019) The wine cake extract suppresses lipopolysaccharide-induced inflammatory responses in RAW264.7 cells. The abstract presented on the 2019 International Student Academic Conference, March 22, 2019, Hsinchu, Taiwan. (Abstract book p.58)
l Su, Y.-S., Lin, H.-H., Chang, H., Hsieh, W.-H., Chuang, L.-T., Chen, Y.-W., and Lin, C. -C. (2019) Application of purple shoot tea for alleviating human metabolic syndrome. The abstract presented on the Asia-Pacific Tea Expo (APTE) 2019 in Japan, March 3-4, 2019, University of Shizuoka, Shizuoka, Japan.
l 莊路德、楊程堯、洪瑞辰 與洪紹文 (2018) 研究靈芝免疫蛋白抑制關節炎的功效。 2018生命教育暨健康管理國際學術研討會，台灣新竹：元培醫事科技大學。 (研討會論文集，2018.10.18，元培醫事科技大學舉行。)
l Chuang, L.-T. and Tsai, P.-J. (2017) Pinolenic acid (PNA) and its elongation metabolite suppress TPA-induced mouse acute skin inflammation. 2017健康管理學術研討會暨臺日健康產業論壇，台灣新竹：元培醫事科技大學。 (研討會論文集 p373. 2017.11.3，元培醫事科技大學舉行。)
l 林志城、蘇彥碩、林秀樺、郭祐豪、莊路德 與張翔 (2017) 紫芽茶機能性成分與抑制脂肪堆積作用。2017台灣農業化學會研討會，台灣台北：國立臺灣大學。 (台灣農化學會第五十五次會員大會手冊議程及論文摘要 p101. 2017.6.24，國立臺灣大學舉行。)
l Tseng, M.-L., and Chuang, L.-T. (2017) Evaluating the effects of stability and sterility assurance on vitamin B-complex injection with various sterilization conditions. The abstract presented on the 2017 International Student Academic Conference, March 24, 2017, Hsinchu, Taiwan. (Abstract book p.96)
l Chen, R.-Y., Li. H.-Y., and Chuang, L.-T. (2017) Pinolenic acid (PNA) modulates pro-inflammatory mediator production in THP-1 macrophages. The abstract presented on the 2017 International Student Academic Conference, March 24, 2017, Hsinchu, Taiwan. (Abstract book p.83)
